Chemical looping applied to reforming of natural gas is a promising technology for hydrogen production. This work focuses on the design and evaluation of a 600 MW (LHV) hydrogen production plant featuring chemical looping with packed bed reactors at high pressure for syngas generation, as part of a project that also includes a business case for small scale hydrogen, blue direct reduced iron (DRI) and renewable methanol production. The study involves simulation of a full-scale plant in Aspen Plus, reactor design based on in-house modelling and key performance indicators to assess the operational and environmental behavior of the proposed plant. The main results of the comprehensive techno-economic analysis (TEA) related to large scale H2 production include the cold gas reforming efficiency of the process (82%), net electricity consumption of 48.75 MW, which results in an energy intensity of 0.081 MW/MWH2 as no thermal energy import is required. The in-situ recovery of CO2 as an additional product stream leads to a carbon capture rate >99%. The economic potential based on operating costs (£260,718,423 per year) accounts for 70% of natural gas, 17% electricity and 13% for CO2 transport and storage. The promising results of blue hydrogen production via chemical looping reforming offer a scalable solution for various industries. This technology, with its lower environmental impact, facilitates the decarbonization of industries currently using hydrogen in their processes and those transitioning to cleaner alternatives such as steel production.