The technology readiness of chemical looping processes is being advanced by transforming batch-mode bench-scale systems into continuously operating pilot units , and these changes in operating mode and scale introduce new levels of risk to process accidents. To ensure pilot plants operate safely and successfully and to sustain external support for the development of chemical looping processes, a rigorous approach is required to integrate process safety management into both design and operation of these systems , especially with limited operating background. Beyond the application of technically sound engineering of individual unit operations, additional considerations are required for safer operations. Hazard identification and risk analysis techniques for pilot plants that should take place during the design and operations stages of a chemical looping facility’s lifecycle are discussed, with some applicable engineered controls provided as initial guidance. The application of inherently safer design principles (minimization, substitution, moderation, and simplification of hazards) as they can apply to chemical looping are evaluated. A selection of these measures are proposed and their feasibility is discussed. Additional administrative control strategies to protect personnel, property, business continuity, and the environment are assessed for a chemical looping pilot plant. Finally, incident reporting and process safety management strategies such as CSA Z767 at the plant level are considered, with the need for safety information sharing in the chemical looping research community highlighted.