In order to mitigate or eradicate the adverse impact of fuel-derived chlorine on Cu-based OC, it is necessary to design the Cu-based OC with chlorine resistance. The objective of this study is to fabricate Cu-based OC containing adsorbents with enhanced resistance against chlorine poisoning. CaO·CuO@Al2O3 and BaO·CuO@Al2O3 OCs (referred to as Ca-OC & Ba-OC, respectively) were synthesized via the sol-gel method. Initially, CH4-HCl mixture was employed as fuel for chemical looping combustion (CLC) under specific conditions (T = 850℃，λ = 1.5). Subsequently, coal and biomass were employed as fuel for CLC under varying conditions (T = 800℃, 850℃, 900℃; λ = 1.5, 2.0, 2.5). The findings revealed that the Ca-OC exhibited superior dechlorination efficiency compared to the Ba-OC in CLC of CH4 with respetive dechlorination efficiencies of Ca- and Ba-OCs being recorded at 94.7% ± 5.4% and 90.0% ± 4.0%. Furthermore, the dechlorination efficiency of Cu-OC was 73.7±3.7% at 850℃. The combustion efficiency and dechlorination efficiency of Cu-OC in CLC of coal and biomass are determined by temperature (T) and oxygen-fuel ratio (λ). In addition, the dechlorination efficiency of Ca-OC in CLC of coal exhibited significant variability with temperature, while the dechlorination efficiency of Ba-OC in CLC of coal and biomass remained at 100% in any case. This study contributes to expanding the potential application of Cu-based OC in CLC.