An understanding of surface-groundwater connections is needed to assess the current state of water resources in Alberta, to support current and future economic, environmental and social resilience. There are multiple methods of estimating groundwater-surface water interaction available, but these have not been fully evaluated and integrated to provide regional perspective of the connectivity of these resources. Tracer-based separations (such as geochemical, stable isotope or thermal indicators) can be valuable methods to groundwater contributions to rivers, but the application of these methods across large areas is limited by data availability. Hydrologic models may be useful in filling the spaces and times between tracer observations, if groundwater processes are simulated with sufficient accuracy. A semi-distributed process-based hydrological model (HYPE) is used to simulate runoff, baseflow and streamflow discharge in watersheds from the Rocky Mountain headwaters to the prairies, with groundwater contributions to streamflow estimated from the ratio of modeled sub-surface outflow to streamflow. This spatially and temporally continuous simulated dataset is compared to hydrometric and tracer estimations of groundwater contributions to assess the accuracy and reliability of the simulation at regional scales.