Tibetan Plateau (TP) has strong land-atmosphere interactions. The rapid climate change on TP alters the soil hydrothermal conditions. It is vital to quantify such changes on the subsequent hydrologic cycle. This study applied multiple statistical analysis and numerical modeling methods to comprehensively address the impact of initial soil hydrothermal conditions on the subsequent hydrologic cycle on TP. The findings are referenceable for the local to downstream hydrology and water resources protection. The new hydrological insights for the region are described as follows: The soil moisture (SM) and soil temperature (ST) on TP have strong association with the hydrometeorological variables (i.e., air temperature (tmp), evapotranspiration (ET), precipitation (prec), runoff). Changtang Plateau and upper sources of Yellow-Yangtze-Mekong river basins outstand as hotspot with strong soil hydrothermal-hydrologic interaction. In the hotspot, the initial short-term SM (ISM) condition exerts positive feedback with the hydrologic cycle: dry (wet) ISM would result in decrease (increase) of ET, prec and runoff. Such impact can last 3-4 months on runoff while vary from 1 to 3 months on prec in different season. The sensitivity of hydrologic cycle to ISM is stronger in spring and autumn than in summer. Compared to ISM, the short-term IST anomalies have weak effect on the subsequent hydrologic cycle. But long-term ST could exert obvious positive impact on ET and prec in the hotspot.