In support of Canada’s energy transition, more than 300 new natural resource developments are identified covering renewable energy, critical minerals and sustainable forestry. New projects will be subject to either project-level Impact Assessments (IAs), or Regional Assessments (RAs) in areas with multiple projects. Socio-economic conditions are an essential component when assessing cumulative effects of natural resource development. Such information requires integration with biophysical and environmental dimension which therefore requires mapping data in a spatially explicit manner. To address this need, a GIS database of Canadian communities was developed using an ‘ecumene’ spatial framework (CanEcumene GDB 3.0) as an alternative to conventional administrative and census boundaries. Two key derivative products from this database include Regional and Community Vitality Index (RVI/CVI) and Labour Force Distribution (LFD) profiles for all of Canada at the community level. This presentation demonstrates how these products are being used in two regional case studies for central western Newfoundland and the Abitibi-Temiscamingue region of Ontario and Quebec. Results reveal important relationships among labour force profiles of natural resource sectors, population stability, employment and education levels, economic wealth, and overall community vitality.