Indigenous people in Canada experience a greater burden of health and social inequities relative to non-Indigenous populations. A history of harmful colonial wardship in Canadian healthcare has limited Indigenous people’s access to wellness and safety within healthcare environments. The emerging role of Indigenous Patient Navigation (IPN) has been identified as a bridge between Western healthcare and Indigenous communities, reducing experiences of harm for patients and their families. Despite the promise of IPN, little research has identified what these roles mean for Indigenous health and wellness in health care environments. This research builds from 13 semi-structured interviews with Indigenous Patient Navigators (IPNs) who work across a range of health care environments in Ontario, Canada. This research examines how they understand their roles, including the ways their environments shape their abilities to do their caring work. The role of IPN holds considerable promise to initiate positive change-making within healthcare environments. This research will offer first-hand accounts from IPNs that share their perceptions of their role, and contributions to garner support among scholars and policy audiences.